METHODS FOR STUDYING AND ASSESSING CYTOGENETIC CHANGES IN BONE MARROW CELLS OF LABORATORY ANIMALS RECEIVING GENE-MODIFIED

The aim was to study cytogenetic changes in bone marrow cells of laboratory animals that received and did not receive a genetically modified (GM) product (GM-soy) comparative aspect. It found the group white outbred rats GM-soy, were red marrow, expressed partial inhibition cell proliferation due cytotoxic effect. They also had polyploidy (5.35%) aneuploidy 10.7% cases. In addition, this contained with mitotic pathology - chromosome scattering, pulverization, impaired spiralization despiralization chromosomes, premature delayed mitosis at prophase stage. soy without GM cells, there metaphase plates normal karyotype. activity control higher (MI 9%) than first 3%) second 5%).